Program

18:00 – 21:00

Registration and Welcome Reception at the Faculty of Veterinary Medicine, Wroclaw University of Environmental and Live Sciences

08:00 – 09:00

Registration

09:00 – 09:15

Opening remarks (Prof. dr hab. D. Skarżyński, Prof. dr hab. Wojciech Niżański)

09:15 – 11:05

Session I: Formation of the CL and maintenance of luteal function

Moderator 1: Agnieszka Rak (Jagiellonian University, Krakow, Poland)
Moderator 2: Mariusz Kowalewski (Vetsuisse Faculty, University of Zurich, Zurich, Switzerland)

Lectures:

09:15 – 09:50

Agnieszka Rak: “A new perspective on the regulation of corpus luteum: expression and role of visfatin (NAMPT) on luteal transcriptome, proteome and functioning”

09:50 – 10:25

Mariusz Kowalewski “Targeted and Global Insights into the Regulation of CL Function in the Dog”

Short oral presentations:

10:25 – 10:45

Vijay Simha Baddela “Single-cell reconstruction of the bovine corpus luteum”

10:45 – 11:05

Karolina Pich “Comparative analysis of expression of omentin-1 in porcine ovarian follicles vs corpus luteum and it’s in vitro effects on proliferation, apoptosis and steroidogenesis”

11:05 – 11:30

Coffee break

11:30 – 14:00

Session II: Regression of CL function and luteal dysfunctions

Moderator 1: Camilla Hughes (Department of Animal Science, College of Agriculture Sciences, University Park, PA, USA)
Moderator 2: Sławomir Wołczyński (Faculty of Medicine, Medical University of Bialystok, Poland)

Lectures:

11:30 – 12:05

Camilla Hughes “Luteal responsiveness to prostaglandin F2: from development to regression”

12:05 – 12:40

Sławomir Wołczyński “Luteal phase defect in women”

Short oral presentations:

12:40 – 13:00

Ewa Młyczyńska “Phoenixin-14 modulates angiogenesis, cell proliferation, and apoptosis in porcine corpus luteum”

13:20 – 13:40

Muhittin Tekin “Effect of heat stress on the mRNA expression in the corpus luteum of dairy cows”

13:40 – 14:00

Marvin Hölper “Corpus luteum diagnostic via ultrasound – A viable tool for treatment decisions in Ovsynch protocols”

14:00 – 14:45

Lunch break

15:00 – 19:00

Ceremonial session at the Collegium Anatomicum, Medical University of Wrocław

15:00 – 15:20

Official opening ceremony:

prof. Piotr Ponikowski – Rector of Medical University of Wroclaw
prof. Krzysztof Kubiak – Rector of Wroclaw University of Environmental and Live Sciences
prof. Bernd Hoffman – Justus-Liebig-Universität Gießen
prof. Jan Twardon – Wroclaw University of Environmental and Live Sciences

15:20 – 16:10

Plenary lecture: John Davis: Control of Luteal Function by Luteinizing Hormone: Insights into multi-organelle control of steroidogenesis (Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE, United States)

16:10 – 16:30

Bernd Hoffmann “Dr Ludwig-Fraenkel – spiritus rector on the early progesterone research”

16:30 – 16:50

Tomasz Fuchs “Progestagens in current human reproductive medicine” (Wrocław Medical University, Poland)

16:50 – 17:10

Malgorzata Ochota “Progestagens in current veterinary reproductive medicine” (Wroclaw University of Environmental and Live Sciences, Wroclaw, Poland )

17:10 – 17:40

Coffee break

17:40 – 19:00

Visiting Medical University of Wroclaw

  • Anatomical Museum & Old Library of Department of Human Morphology and Embryology – prof. Marek Syrycki
  • Place where Dr Fraenkel and Dr Slota worked to discover and characterize progesterone (former Dep. of Gynecology and Obstetrics) – prof. Tomasz Fuchs

    09:00 – 09:45

    Plenary lecture: prof. Milo Wiltbank (Department of Dairy Science, University of Wisconsin-Madison, Madison, USA)

    09:45 – 10:15

    Coffee break

    10:15 – 13:00

    Session III: Ovarian-oviductal-uterine interactions during the estrous cycle and early pregnancy

    Moderator 1: Dimitrios Rizos (Dept. of Animal Reproduction, INIA-CSIC, Madrid, Spain)
    Moderator 2: Graca M. Ferreira-Dias (Faculty of Veterinary Medicine, Lisbon University, Lisbon. Portugal)

    Lectures:

    10:15 – 10:50

    Dimitrios Rizos “Current insights into Preimplantation Embryo-Maternal Communication in Cows”

    10:50 – 11:20

    Graca M. Ferreira-Dias “Mare endometrium disorders: Inflammation, Fibrosis, and Therapeutic approaches”

    Short oral presentations:

    11:20 – 11:40

    Saumya Gunasekara “Determination of Porcine Follicular Fluid Extracellular Vesicles Effect on Boar Spermatozoa Survival In Vitro”

    11:40 – 12:00

    Edith Maria Habich “Relationship between the epithelial immune response in the uterus and oviduct in postpartum dairy cows”

    12:00 – 13:00

    Poster session / Coffee break

    13:00 – 14:00

    Lunch

    14:00 – 17:00

    Session IV: Etiology and pathogenesis of uterine disorders

    Moderator 1: Fidel Ovidio Castro (Animal Biotechnology Lab at University of Concepción, Chile)
    Moderator 2: Anna Z. Szóstek-Mioduchowska (Department of Reproductive Immunology and Pathology, IAR&FR PAS Olsztyn)

    Lectures:

    14:00 – 14:35

    Fidel Ovidio Castro “The impact of TGFβ1, mesenchymal stem cells, and extracellular vesicles on equine in vitro endometrial fibrosis models”

    14:35 – 15:10

    Anna Z. Szóstek-Mioduchowska “Fibroblasts as key regulators of endometrial fibrosis in the mare: insights from transcriptomic and functional analysis”

    15:10 – 15:40

    Coffee break

    Short oral presentations:

    15:40 – 16:00

    Lei Xie “Transcriptomic landscapes of the endometrium in dairy cows with clinical or subclinical endometritis”

    16:00 – 16:20

    Joana Alpoim-Moreira “The effect of the demethylating agent decitabine on collagen expression in mare endometrial fibroblasts treated with elastase”

    16:20 – 16:40

    Natacha Murderspach “Mapping of the plasma and endometrial proteome of mares with healthy and fibrotic endometria”

    16:40 – 17:00

    Agnieszka Sadowska “The potential role of IL-17 in the processes associated with the development of endometrosis”

    Gala dinner – at the cruise on Odra River

    09:00 – 09:45

    Plenary lecture: Stephen LeBlanc “Metabolic and reproductive health in dairy cows” (Ontario Veterinary College, University of Guelph, Ontario, Canada)

    09:45 – 10:15

    Coffee break

    10:15 – 13:00

    Session V: New diagnostic tools of uterine disorders in farm animals

    Moderator 1: Tal Raz (Jerusalem Hebrew Univ. Rehovot, Israel)
    Moderator 2: Mette Christoffersen (University of Copenhagen, Department of Veterinary Clinical Sciences; Copenhagen, Dennmark)

    Lectures:

    10:15 – 10:50

    Tal Raz “Metagenetics of the female reproductive tract: opportunities, challenges, and lessons learned”

    10:50 – 11:25

    Mette Christoffersen “Update on diagnostic procedures for equine endometritis”

    11:25 – 12:00

    Coffee break

    Short oral presentations:

    12:00 – 12:20

    Muhammad Hussnain Rashid “Functional metagenomics of endometrial cytology samples from dairy cows diagnosed with clinical or subclinical endometritis”

    12:20 – 12:40

    Laura Vanina Madoz “Comparative analysis of antimicrobial resistance through whole genome sequencing in healthy and metritic cows and their environmentv”

    12:40 – 13:00

    Pritt Karis: “The association of cytological endometritis with insulin resistance and gene expression in adipose tissue in transition dairy cows”

    13:00 – 14:00

    Lunch

    14:00 – 16:50

    Session VI: Therapy of uterine disorders in farm animals

    Moderator 1: Igor Canisso (College of Veterinary Medicine, University of Illinois, Urbana, IL, USA)
    Moderator 2: Geert Opsomer (Faculty of Veterinary Medicine, Ghent University, Belgium)

    Lectures:

    14:00 – 14:35

    Dr Igor Canisso

    14:35 – 15:10

    Prof. Geert Opsomer “New insights in the treatment and control of postpartum uterine disease in high-yielding dairy cows”

    15:10 – 15:40

    Coffee break

    Short oral presentations:

    15:40 – 16:00

    Rodolfo Luzbel de la Sota “The addition of meloxicam to the treatment of clinical and subclinical mastitis improved the cure rate and fertility in dairy cows in Ecuador”

    16:00 – 16:20

    Ahmet Cihad Gok “Mechanisms regulating the protection of mammalian cells against damage caused by cholesterol-dependent cytolysins from pathogenic bacteria”

    16:20 – 16:50

    Marta Marcinek “Antimicrobial effects of cold plasma-activated solutions against selected bacteria causing endometritis in mares: an in vitro preliminary study”

    16:50

    Closing Ceremony, Awarding of best presentation and poster

    19:00

    Get to know the old – Piast Wrocław – a tour of Wrocław

    08:00

    Open Workshop and Discussion on animal behavior, welfare and health: “Whether large farm animals could be alternative research models for biomedical study?” with scientific and historical excursion to Swidnica, Książ Castel and Książ Horse State Stud